Cholecalciferol
Posted on 22 November 2009
Can you explain the relationship between levels of prohormones ergocalciferol and cholecalciferol and LTL?
Vitamin D may have an impact around the blood leukocyte telomere length. Richards and coworkers examined whether vitamin D concentrations can slow the rate of shortening of leukocyte telomeres. The authors expressed Vitamin D is a potent inhibitor of proinflammatory response and slows the turnover of leukocytes. Leukocyte telomere length (LTL) predicted the development of aging-related disease, and the length of telomeres decreases with each cell division and increased with inflammation. Researchers measured serum vitamin D concentrations in 2160 women aged 18-79 who years (mean age: 49.4) from a large population-based set of twins. This study group was divided into thirds based on the levels of vitamin D, and found that increased The age was significantly associated with shorter LTL (r = -0.40, P <0.0001). Higher serum vitamin D concentrations were significantly associated with the LTL (r = 0.07, P = 0.0010), and this finding persisted even after adjustment for age (r = 0.09, P <0.0001) and other independent variables that affect LTL (age, season of vitamin D measurement, menopausal status, use of hormone replacement therapy, and physical activity). The difference between LTL the highest and lowest tertiles of vitamin D is highly significant (P = 0.0009), and the author declared that it is equivalent to 5.0 years of aging. The authors concluded that higher Vitamin D Levels (easy modifiable through nutritional supplementation) is associated with LTL, which underscores the potentially beneficial effects of vitamin D in aging and age-related disease. As a measure of systemic telomere length, in general, peripheral blood leukocyte telomere length is preferred. Systemic telomere length is proposed as a marker of biological aging. The topic of systemic telomere length is mostly genetically determined, but there are some other known determinants: age (shorter telomeres in older people), a father at the age of birth (which telomeres in subjects with older fathers at their birth) and sex (shorter telomeres in humans, perhaps due to a faster that telomere attrition). Evidence suggests that high levels of oxidative stress and inflammation to further increase the rate of telomere attrition. Vitamin D is a group of fat-soluble prohormones, the two main methods of which are vitamin D2 (or ergocalciferol) and vitamin D3 (or cholecalciferol). The term vitamin D also refers to metabolites and analogues of other elements. Vitamin D3 is produced in skin exposed to sunlight, specifically ultraviolet B radiation.
Vitamin D3 (Cholecalciferol)
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